Annotation Detail
Information
- Associated Genes
- CYP3A4
- Associated Variants
-
CYP3A4 MUTATION
CYP3A4 MUTATION
CYP3A4 p.Met445Thr (p.M445T) ( ENST00000336411.7, ENST00000354593.6, ENST00000651514.1, ENST00000652018.1 )
CYP3A4 p.Met445Thr (p.M445T) ( ENST00000336411.7, ENST00000354593.6, ENST00000651514.1, ENST00000652018.1 ) - Associated Disease
- Malignant neoplasm of breast
- Source Database
- DisGeNET
- Description
- In multivariate analyses, we observed a significantly decreased risk of breast cancer associated with the CYP3A4 M445T minor allele (rs4986910, OR = 0.3; 95% CI 0.1-0.9).
- Pubmed
- 19214745
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0495881194188037
- Year of publication
- 2009
Drugs