Annotation Detail
Information
- Associated Genes
- BRCA1
- Associated Variants
-
LSP1 c.*13+200T>C
(
ENST00000381775.5,
ENST00000311604.8,
ENST00000612798.4,
ENST00000405957.6,
ENST00000406638.6 )
LSP1 c.*13+200T>C ( ENST00000311604.8, ENST00000381775.5, ENST00000405957.6, ENST00000406638.6, ENST00000612798.4 ) - Associated Disease
- Malignant neoplasm of breast
- Source Database
- DisGeNET
- Description
- There was significant association between LSP1 rs3817198T>C polymorphism and breast cancer risk in BRCA1 and BRCA2 positive cohort in all comparison models (the allele contrast model: OR = 1.08, 95% CI = 1.03-1.13; CC vs. TT: OR = 1.16, 95% CI = 1.05-1.29; TC vs. TT: OR = 1.09, 95% CI = 1.01-1.16; the dominant model: OR = 1.10, 95% CI = 1.03-1.17; the recessive model: OR = 1.12, 95% CI = 1.01-1.23).
- Pubmed
- 21127985
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.36
- Year of publication
- 2011
Drugs