Annotation Detail
Information
- Associated Genes
- TLR4
- Associated Variants
-
TLR2 p.Ser450= (p.S450=)
(
ENST00000260010.7,
ENST00000642580.1,
ENST00000642700.2,
ENST00000643501.2,
ENST00000646219.2,
ENST00000646900.2,
ENST00000714431.1,
ENST00000714432.1,
ENST00000714433.1,
ENST00000714434.1,
ENST00000714435.1,
ENST00000714436.1 )
ENSG00000285082 c.140+3714T>C, TLR4 p.Ser105= (p.S105=) ( ENST00000355622.8, ENST00000394487.5, ENST00000472304.2 )
TLR2 p.Ser450= (p.S450=) ( ENST00000260010.7, ENST00000642580.1, ENST00000642700.2, ENST00000643501.2, ENST00000646219.2, ENST00000646900.2, ENST00000714431.1, ENST00000714432.1, ENST00000714433.1, ENST00000714434.1, ENST00000714435.1, ENST00000714436.1 )
ENSG00000285082 c.140+3714T>C, TLR4 p.Ser105= (p.S105=) ( ENST00000355622.8, ENST00000394487.5, ENST00000472304.2 ) - Associated Disease
- measles
- Source Database
- DisGeNET
- Description
- The major alleles of coding SNPs in the TLR2 (rs3804100) and TLR4 (rs5030710) genes were associated with a dose-related increase (660 vs. 892 mIU/ml, p = 0.002) and a dose-related decrease (2,209 vs. 830 mIU/ml, p = 0.001) in measles-specific antibodies, respectively.
- Pubmed
- 21424379
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00081432561624091
- Year of publication
- 2011
Drugs