Annotation Detail
Information
- Associated Genes
- PNPLA3
- Associated Variants
-
PNPLA3 p.Ile148Met (p.I148M)
(
ENST00000216180.8,
ENST00000423180.2 )
AGTR1 c.-48+10558T>C ( ENST00000349243.8, ENST00000404754.2, ENST00000418473.7, ENST00000497524.5 )
AGTR1 c.-48+14340A>G ( ENST00000349243.8, ENST00000404754.2, ENST00000418473.7, ENST00000497524.5 )
PNPLA3 p.Ile148Met (p.I148M) ( ENST00000216180.8, ENST00000423180.2 )
AGTR1 c.-48+10558T>C ( ENST00000349243.8, ENST00000404754.2, ENST00000418473.7, ENST00000497524.5 )
AGTR1 c.-48+14340A>G ( ENST00000349243.8, ENST00000404754.2, ENST00000418473.7, ENST00000497524.5 ) - Associated Disease
- Non-alcoholic Fatty Liver Disease
- Source Database
- DisGeNET
- Description
- Gene-gene interaction between the AGTR1 gene and the patatin-like phospholipase domain-containing 3 (PNPLA3) gene, which we previously reported as associated with NAFLD in this sample, showed a strong interaction between AGTR1 (rs3772627), AGTRI (rs3772630) and PNPLA3 (rs738409) polymorphisms on NAFLD susceptibility (p = 0.007).
- Pubmed
- 23484035
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.264896707361267
- Year of publication
- 2013
Drugs