Annotation Detail

Information
Associated Genes
CASP8
Associated Variants
CASP9 p.Gln221Arg (p.Q221R) ( ENST00000333868.10, ENST00000546424.5, ENST00000348549.9, ENST00000375890.8 )
CASP10 p.Ser59= (p.S59=) ( ENST00000471191.2, ENST00000286186.11, ENST00000272879.9, ENST00000313728.12, ENST00000374650.8, ENST00000346817.10, ENST00000448480.1, ENST00000696199.1 )
CASP8 c.*845T>A ( ENST00000323492.11, ENST00000358485.8, ENST00000413726.6, ENST00000444430.3, ENST00000673742.1, ENST00000696067.1, ENST00000696069.1, ENST00000696085.1, ENST00000696087.1 )
CASP3 c.*1296C>A ( ENST00000308394.9, ENST00000393585.6, ENST00000523916.5, ENST00000700100.1, ENST00000700101.1 )
CASP3 c.*337T>C ( ENST00000308394.9, ENST00000393585.6, ENST00000523916.5, ENST00000700100.1, ENST00000700101.1 )
CASP9 p.Gln221Arg (p.Q221R) ( ENST00000333868.10, ENST00000348549.9, ENST00000375890.8, ENST00000546424.5 )
CASP10 p.Ser59= (p.S59=) ( ENST00000272879.9, ENST00000286186.11, ENST00000313728.12, ENST00000346817.10, ENST00000374650.8, ENST00000448480.1, ENST00000471191.2, ENST00000696199.1 )
CASP8 c.*845T>A ( ENST00000323492.11, ENST00000358485.8, ENST00000413726.6, ENST00000444430.3, ENST00000673742.1, ENST00000696067.1, ENST00000696069.1, ENST00000696085.1, ENST00000696087.1 )
CASP3 c.*1296C>A ( ENST00000308394.9, ENST00000393585.6, ENST00000523916.5, ENST00000700100.1, ENST00000700101.1 )
CASP3 c.*337T>C ( ENST00000308394.9, ENST00000393585.6, ENST00000523916.5, ENST00000700100.1, ENST00000700101.1 )
Associated Disease
Lymphoma, Non-Hodgkin
Source Database
DisGeNET
Description
We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3-171A>G (rs3900115) to determine whether they alter risk for non-Hodgkin lymphoma (NHL) in a population-based case-control study of women in Connecticut (461 cases and 535 controls).
Pubmed
17071630
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.0076439796799667
Year of publication
2007
Drugs