Annotation Detail
Information
- Associated Genes
- CCDC170
- Associated Variants
-
MECOM c.375+16342C>T
(
ENST00000494292.6,
ENST00000651503.2 )
CLPTM1L c.1316-153G>A ( ENST00000320895.10, ENST00000507807.3, ENST00000630539.1 )
CCDC170 c.1294-129G>A ( ENST00000239374.8 )
MECOM c.375+16342C>T ( ENST00000494292.6, ENST00000651503.2 )
CLPTM1L c.1316-153G>A ( ENST00000320895.10, ENST00000507807.3, ENST00000630539.1 )
CCDC170 c.1294-129G>A ( ENST00000239374.8 ) - Associated Disease
- Nasopharyngeal carcinoma
- Source Database
- DisGeNET
- Description
- Three SNPs (rs401681, rs6774494 and rs3757318) corresponding to TERT/CLPTM1L (OR 95% CI = 0.77, 0.68-0.88), MDS1-EVI1 (OR 95% CI=0.79 0.69-0.89) and CCDC170 (OR 95% CI = 0.76, 0.66-0.86) conferred modest protective effects individually for NPC risk by the logistic regression analysis after multiple testing adjustment (p(Bonferroni) < 0.05).
- Pubmed
- 24615621
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2014
Drugs