Annotation Detail

Information
Associated Genes
NQO1
Associated Variants
TXNRD1 c.304+7698C>T ( ENST00000525566.6 )
TXNRD1 c.304+7698C>T ( ENST00000525566.6 )
Associated Disease
Leukemia, Lymphocytic, Acute, L1
Source Database
DisGeNET
Description
Further, at least two studies now show that the inactivating NAD(P)H:quinone acceptor oxidoreductase (NQO1) C609T polymorphism is positively associated with leukemias arising in the first 1-2 years of life and polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene have been associated with adult and childhood ALL.
Pubmed
15967214
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.0110967791468899
Year of publication
2005
Drugs