Annotation Detail
Information
- Associated Genes
- IDH2
- Associated Variants
-
IDH2 MUTATION
IDH2 MUTATION - Associated Disease
- Hematologic Neoplasms
- Source Database
- DisGeNET
- Description
- IDH1- and IDH2-mutant primary human AML cells were more sensitive than IDH1/2 wild-type cells to ABT-199, a highly specific BCL-2 inhibitor that is currently in clinical trials for hematologic malignancies, both ex vivo and in xenotransplant models.
- Pubmed
- 25599133
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 3
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00190009310456212
Drugs