Annotation Detail
Information
- Associated Genes
- KIF2C
- Associated Variants
-
ENSG00000275778 c.-125-12532G>A, TAS2R50 p.Cys203Tyr (p.C203Y)
(
ENST00000506868.1,
ENST00000703543.1 )
VAMP8 c.*143T>C ( ENST00000263864.10, ENST00000409760.1, ENST00000432071.1 )
VAMP8 c.*143T>G ( ENST00000263864.10, ENST00000409760.1, ENST00000432071.1 )
LPA p.Ile1891Met (p.I1891M) ( ENST00000316300.10 )
KIF6 p.Trp719Arg (p.W719R) ( ENST00000229913.9, ENST00000287152.12, ENST00000394362.5, ENST00000538893.5 )
ENSG00000275778 c.-125-12532G>A, TAS2R50 p.Cys203Tyr (p.C203Y) ( ENST00000506868.1, ENST00000703543.1 )
VAMP8 c.*143T>C ( ENST00000263864.10, ENST00000409760.1, ENST00000432071.1 )
VAMP8 c.*143T>G ( ENST00000263864.10, ENST00000409760.1, ENST00000432071.1 )
LPA p.Ile1891Met (p.I1891M) ( ENST00000316300.10 )
KIF6 p.Trp719Arg (p.W719R) ( ENST00000229913.9, ENST00000287152.12, ENST00000394362.5, ENST00000538893.5 ) - Associated Disease
- Coronary heart disease
- Source Database
- DisGeNET
- Description
- Single nucleotide polymorphisms (SNPs) at the KIF6 (kinesin like protein 6, rs20455 or 719Arg), LPA (lipoprotein(a), rs3798220), TAS2R50 (taste receptor type 2, member 50, rs1376251) and VAMP8 (vesicle-associated membrane protein 8, rs1010) have previously been associated with low density lipoprotein cholesterol (LDL-C) lowering response to statins, coronary heart disease (CHD) at baseline, or CHD events on trial.
- Pubmed
- 22192511
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00108576748832121
- Year of publication
- 2012
Drugs