Annotation Detail
Information
- Associated Genes
- ARMS2
- Associated Variants
-
ARMS2 p.Ala69Ser (p.A69S)
(
ENST00000528446.1 )
C3 p.Arg102Gly (p.R102G) ( ENST00000245907.11, ENST00000695693.1 )
ARMS2 p.Ala69Ser (p.A69S) ( ENST00000528446.1 )
C3 p.Arg102Gly (p.R102G) ( ENST00000245907.11, ENST00000695693.1 ) - Associated Disease
- Geographic Atrophy
- Source Database
- DisGeNET
- Description
- Analyzing the currently largest dataset on GA lesion growth (N = 388), our findings suggest a significant and independent contribution of three factors on GA lesion growth including at least two genetic factors (ARMS2_rs10490924 [P < 0.00088] and C3_rs2230199 [P < 0.00015]) as well as one clinical component (presence of GA in the fellow eye [P < 0.00023]).
- Pubmed
- 25962167
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00981551465660913
- Year of publication
- 2015
Drugs