Annotation Detail
Information
- Associated Genes
- ARMS2
- Associated Variants
-
ARMS2 p.Ala69Ser (p.A69S)
(
ENST00000528446.1 )
HTRA1 c.-625G>A ( ENST00000648167.1 )
ARMS2 p.Ala69Ser (p.A69S) ( ENST00000528446.1 )
HTRA1 c.-625G>A ( ENST00000648167.1 ) - Associated Disease
- age related macular degeneration
- Source Database
- DisGeNET
- Description
- The HTRA1 promoter SNP (rs11200638) and A69S at LOC387715/ARMS2 were associated with a poorer visual outcome for ranibizumab or bevacizumab treatment in neovascular AMD, suggesting strong pharmacogenetic associations with anti-VEGF treatment.
- Pubmed
- 23582991
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.403743137904031
- Year of publication
- 2013
Drugs