Annotation Detail

Information
Associated Genes
MUTYH
Associated Variants
MUTYH p.Gln335His (p.Q335H), ENSG00000288208 p.Gln506His (p.Q506H) ( ENST00000456914.7, ENST00000529984.5, ENST00000528013.6, ENST00000372115.7, ENST00000488731.6, ENST00000529892.6, ENST00000372104.5, ENST00000354383.10, ENST00000448481.5, ENST00000483127.2, ENST00000355498.6, ENST00000372098.7, ENST00000372110.7, ENST00000412971.6, ENST00000531105.5, ENST00000713751.1, ENST00000672314.2, ENST00000672818.3, ENST00000710952.2, ENST00000713750.1 )
MUTYH p.Val22Met (p.V22M), ENSG00000288208 p.Val190Met (p.V190M) ( ENST00000528013.6, ENST00000529984.5, ENST00000531105.5, ENST00000456914.7, ENST00000488731.6, ENST00000372115.7, ENST00000372110.7, ENST00000412971.6, ENST00000448481.5, ENST00000372098.7, ENST00000529892.6, ENST00000354383.10, ENST00000355498.6, ENST00000372104.5, ENST00000483127.2, ENST00000672314.2, ENST00000672818.3, ENST00000710952.2, ENST00000713750.1, ENST00000713751.1 )
MUTYH p.Gln335His (p.Q335H), ENSG00000288208 p.Gln506His (p.Q506H) ( ENST00000354383.10, ENST00000355498.6, ENST00000372098.7, ENST00000372104.5, ENST00000372110.7, ENST00000372115.7, ENST00000412971.6, ENST00000448481.5, ENST00000456914.7, ENST00000483127.2, ENST00000488731.6, ENST00000528013.6, ENST00000529892.6, ENST00000529984.5, ENST00000531105.5, ENST00000672314.2, ENST00000672818.3, ENST00000710952.2, ENST00000713750.1, ENST00000713751.1 )
MUTYH p.Val22Met (p.V22M), ENSG00000288208 p.Val190Met (p.V190M) ( ENST00000354383.10, ENST00000355498.6, ENST00000372098.7, ENST00000372104.5, ENST00000372110.7, ENST00000372115.7, ENST00000412971.6, ENST00000448481.5, ENST00000456914.7, ENST00000483127.2, ENST00000488731.6, ENST00000528013.6, ENST00000529892.6, ENST00000529984.5, ENST00000531105.5, ENST00000672314.2, ENST00000672818.3, ENST00000710952.2, ENST00000713750.1, ENST00000713751.1 )
Associated Disease
Malignant neoplasm of lung
Source Database
DisGeNET
Description
We identified three common coding region (V22M, Q324H and S501F) and intronic (157+30A>G, 462+35G>A and 1435-40G>C) variants, but none were over-represented in the patient samples, indicating that MYH variants are unlikely to predispose significantly to the risk of lung cancer.
Pubmed
14579148
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.00872974716828791
Year of publication
2004
Drugs