Annotation Detail
Information
- Associated Genes
- XRCC2
- Associated Variants
-
XRCC2 p.Arg188His (p.R188H)
(
ENST00000359321.2,
ENST00000698506.1 )
XRCC2 p.Arg188His (p.R188H) ( ENST00000359321.2, ENST00000698506.1 ) - Associated Disease
- breast carcinoma
- Source Database
- DisGeNET
- Description
- We observed that the XRCC2 R188H polymorphism modified the association of plasma alpha-carotene level and breast cancer risk (test for ordinal interaction, P=0.03); the significantly decreased risk seen overall for women in the highest quartile of plasma alpha-carotene was only present among 188H non-carriers (the top quartile versus the bottom quartile; multivariate odds ratio, 0.55; 95% confidence interval, 0.40-0.75).
- Pubmed
- 14578164
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00542883744160607
- Year of publication
- 2004
Drugs