Annotation Detail

Information
Associated Genes
NLRP3
Associated Variants
NLRP3 p.Arg260Ter (p.R260*) ( ENST00000366496.7, ENST00000348069.7, ENST00000474792.2, ENST00000391827.3, ENST00000391828.8, ENST00000336119.8, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Val262Ala (p.V262A) ( ENST00000643234.2, ENST00000348069.7, ENST00000366496.7, ENST00000336119.8, ENST00000697350.1, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000697408.2 )
NLRP3 p.Val262Gly (p.V262G) ( ENST00000474792.2, ENST00000391828.8, ENST00000391827.3, ENST00000697408.2, ENST00000366496.7, ENST00000348069.7, ENST00000643234.2, ENST00000697350.1, ENST00000336119.8 )
NLRP3 p.Gly301Ser (p.G301S) ( ENST00000697350.1, ENST00000336119.8, ENST00000643234.2, ENST00000348069.7, ENST00000366496.7, ENST00000697408.2, ENST00000391828.8, ENST00000474792.2, ENST00000391827.3 )
NLRP3 p.Gly301Cys (p.G301C) ( ENST00000366496.7, ENST00000643234.2, ENST00000348069.7, ENST00000336119.8, ENST00000697350.1, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000697408.2 )
NLRP3 p.Asp303Asn (p.D303N) ( ENST00000336119.8, ENST00000474792.2, ENST00000391827.3, ENST00000348069.7, ENST00000366496.7, ENST00000391828.8, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Asp303His (p.D303H) ( ENST00000474792.2, ENST00000391827.3, ENST00000391828.8, ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Ala439Thr (p.A439T) ( ENST00000348069.7, ENST00000697350.1, ENST00000336119.8, ENST00000643234.2, ENST00000366496.7, ENST00000697408.2, ENST00000391828.8, ENST00000474792.2, ENST00000391827.3 )
NLRP3 p.Ala439Pro (p.A439P) ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Arg260Ter (p.R260*) ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Val262Ala (p.V262A) ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Val262Gly (p.V262G) ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Gly301Ser (p.G301S) ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Gly301Cys (p.G301C) ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Asp303Asn (p.D303N) ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Asp303His (p.D303H) ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Ala439Thr (p.A439T) ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
NLRP3 p.Ala439Pro (p.A439P) ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
Associated Disease
Amyloid nephropathy
Source Database
DisGeNET
Description
Muckle-Wells syndrome was most likely, although no amyloid nephropathy was observed and no gene mutations of CIAS1 (T785C, C778T, G907A, G1315A, G1075C) were detected.
Pubmed
16556280
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.000542883744160607
Year of publication
2006
Drugs