Annotation Detail

Information
Associated Genes
PRNP
Associated Variants
PRNP p.Glu200Lys (p.E200K) ( ENST00000379440.9, ENST00000424424.2, ENST00000430350.2, ENST00000457586.2 )
PRNP p.Glu200Lys (p.E200K) ( ENST00000379440.9, ENST00000424424.2, ENST00000430350.2, ENST00000457586.2 )
Associated Disease
Prion Diseases
Source Database
DisGeNET
Description
To investigate this possibility, we looked into the time related changes of PrP proteins in the brains of TgMHu2ME199K/wt mice, a line modeling for heterozygous genetic prion disease linked to the E200K PrP mutation.
Pubmed
23922744
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.481088376032419
Year of publication
2013
Drugs