Annotation Detail
Information
- Associated Genes
- JAK1
- Associated Variants
-
JAK1 MUTATION
JAK1 MUTATION - Associated Disease
- pancreatic carcinoma
- Source Database
- DisGeNET
- Description
- Together, our data demonstrate that TPCA-1 is a unique dual inhibitor of IKK-β and JAK1 kinase, and provide a new evidence that upregulated type I interferon signaling plays a major role in resistance of pancreatic cancer cells to oncolytic viruses.
- Pubmed
- 26331681
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs