Annotation Detail

Information
Associated Genes
DNAH8
Associated Variants
TPM1 p.Asp217Asn (p.D217N) ( ENST00000559556.5, ENST00000559397.6, ENST00000560970.6, ENST00000561266.6, ENST00000357980.9, ENST00000358278.7, ENST00000317516.12, ENST00000560615.6, ENST00000334895.10, ENST00000560959.5, ENST00000403994.9, ENST00000558910.3, ENST00000559281.6, ENST00000288398.10, ENST00000404484.9, ENST00000267996.11, ENST00000651704.1, ENST00000714013.1, ENST00000651577.1, ENST00000714014.1, ENST00000714017.1 )
TPM1 p.Glu222Gly (p.E222G) ( ENST00000714013.1, ENST00000651577.1, ENST00000559397.6, ENST00000714014.1, ENST00000357980.9, ENST00000404484.9, ENST00000559281.6, ENST00000560615.6, ENST00000651704.1, ENST00000288398.10, ENST00000403994.9, ENST00000358278.7, ENST00000561266.6, ENST00000559556.5, ENST00000560959.5, ENST00000714017.1, ENST00000267996.11, ENST00000317516.12, ENST00000334895.10, ENST00000560970.6, ENST00000558910.3 )
TPM1 p.Glu222Val (p.E222V) ( ENST00000651704.1, ENST00000560615.6, ENST00000403994.9, ENST00000288398.10, ENST00000404484.9, ENST00000559281.6, ENST00000714014.1, ENST00000559397.6, ENST00000357980.9, ENST00000714013.1, ENST00000651577.1, ENST00000560970.6, ENST00000558910.3, ENST00000334895.10, ENST00000714017.1, ENST00000267996.11, ENST00000317516.12, ENST00000559556.5, ENST00000560959.5, ENST00000358278.7, ENST00000561266.6 )
TPM1 p.Asp217Asn (p.D217N) ( ENST00000267996.11, ENST00000288398.10, ENST00000317516.12, ENST00000334895.10, ENST00000357980.9, ENST00000358278.7, ENST00000403994.9, ENST00000404484.9, ENST00000558910.3, ENST00000559281.6, ENST00000559397.6, ENST00000559556.5, ENST00000560615.6, ENST00000560959.5, ENST00000560970.6, ENST00000561266.6, ENST00000651577.1, ENST00000651704.1, ENST00000714013.1, ENST00000714014.1, ENST00000714017.1 )
TPM1 p.Glu222Gly (p.E222G) ( ENST00000267996.11, ENST00000288398.10, ENST00000317516.12, ENST00000334895.10, ENST00000357980.9, ENST00000358278.7, ENST00000403994.9, ENST00000404484.9, ENST00000558910.3, ENST00000559281.6, ENST00000559397.6, ENST00000559556.5, ENST00000560615.6, ENST00000560959.5, ENST00000560970.6, ENST00000561266.6, ENST00000651577.1, ENST00000651704.1, ENST00000714013.1, ENST00000714014.1, ENST00000714017.1 )
TPM1 p.Glu222Val (p.E222V) ( ENST00000267996.11, ENST00000288398.10, ENST00000317516.12, ENST00000334895.10, ENST00000357980.9, ENST00000358278.7, ENST00000403994.9, ENST00000404484.9, ENST00000558910.3, ENST00000559281.6, ENST00000559397.6, ENST00000559556.5, ENST00000560615.6, ENST00000560959.5, ENST00000560970.6, ENST00000561266.6, ENST00000651577.1, ENST00000651704.1, ENST00000714013.1, ENST00000714014.1, ENST00000714017.1 )
Associated Disease
Cardiomyopathies
Source Database
DisGeNET
Description
To understand how the HCM-causing Asp175Asn and Glu180Gly mutations in α-tropomyosin affect on actin-myosin interaction during the ATPase cycle, we labeled the SH1 helix of myosin subfragment-1 and the actin subdomain-1 with the fluorescent probe N-iodoacetyl-N'-(5-sulfo-1-naphtylo)ethylenediamine.
Pubmed
22155441
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.00190009310456212
Year of publication
2012
Drugs