Annotation Detail
Information
- Associated Genes
- NPAS2
- Associated Variants
-
NPAS2 MUTATION
NPAS2 MUTATION
NPAS2 p.Thr394Ala (p.T394A) ( ENST00000335681.10 )
NPAS2 p.Thr394Ala (p.T394A) ( ENST00000335681.10 ) - Associated Disease
- Malignant neoplasm of breast
- Source Database
- DisGeNET
- Description
- However, when accounting for potential effect modification, rs23051560 (Ala394Thr) in the largest circadian gene, Neuronal PAS domain protein 2 (NPAS2) was most strongly associated with breast cancer risk (nominal test for interaction p-value = 0.0005; 10,000-permutation-based main-effects p-value among women with < 24 months of shift-work = 0.003).
- Pubmed
- 22473669
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00900118904036822
- Year of publication
- 2012
Drugs