Annotation Detail
Information
- Associated Genes
- FGFR4
- Associated Variants
-
FGFR4 MUTATION
FGFR4 MUTATION - Associated Disease
- Rhabdomyosarcoma, Embryonal
- Source Database
- DisGeNET
- Description
- Preclinical studies have demonstrated that resistance to FGFR inhibitors can be acquired through mutations in the FGFR gatekeeper residue, as clinically observed for FGFR4 in embryonal rhabdomyosarcoma and neuroendocrine breast carcinomas.
- Pubmed
- 25349422
- Section of the abstract supporting the evidence
- ALL_TEXT_1/3
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 3
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs