Annotation Detail
Information
- Associated Genes
- TP63
- Associated Variants
-
TP63 MUTATION
TP63 MUTATION - Associated Disease
- Tumor Progression
- Source Database
- DisGeNET
- Description
- In parallel, although the tumor-suppressor p53 acts as the first barrier against tumor transformation, its inactivation also appears to be crucial for enabling cancer progression at advanced stages. p53 has been proposed to antagonize HIF, and emerging evidence suggests that the p53 siblings p63 and p73 also participate in this interplay.
- Pubmed
- 26032560
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 2
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00217153497664243
Drugs