Annotation Detail
Information
- Associated Genes
- TERT
- Associated Variants
-
TERT MUTATION
TERT MUTATION - Associated Disease
- Tumor Progression
- Source Database
- DisGeNET
- Description
- We demonstrate that binding of ETS to the mutant TERT promoter is insufficient in driving its transcription but this process requires non-canonical NF-κB signalling for stimulus responsiveness, sustained telomerase activity and hence cancer progression.
- Pubmed
- 26389665
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 4
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00352874433704394
Drugs