Annotation Detail
Information
- Associated Genes
- AGTR1
- Associated Variants
-
AGTR1 MUTATION
AGTR1 MUTATION - Associated Disease
- Aortic Aneurysm, Thoracic
- Source Database
- DisGeNET
- Description
- By demonstrating that promiscuous AT1r and TGFβ drive partially overlapping processes of arterial disease in MFS mice, our study argues for a therapeutic strategy against TAA that targets both signaling pathways although sparing the early protective role of TGFβ.
- Pubmed
- 25614286
- Section of the abstract supporting the evidence
- CONCLUSIONS
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 9
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs