Annotation Detail
Information
- Associated Genes
- AGT
- Associated Variants
-
AGT MUTATION
AGT MUTATION - Associated Disease
- Aortic Aneurysm, Thoracic
- Source Database
- DisGeNET
- Description
- Using a loss-of-function genetic mouse model, we demonstrated that the lack of Mmp17 resulted in the presence of dysfunctional vascular smooth muscle cells and altered extracellular matrix in the vessel wall; and it led to increased susceptibility to angiotensin-II-induced thoracic aortic aneurysm.
- Pubmed
- 25963716
- Section of the abstract supporting the evidence
- METHODS AND RESULTS
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree,GAD
- DisGENET score for the Gene Disease association
- 0.00318135759484294
Drugs