Annotation Detail
Information
- Associated Genes
- CASP8
- Associated Variants
-
CASP8 c.-937_-932del
CASP8 c.-937_-932del
CASP7 p.Asp340Glu (p.D340E) ( ENST00000452490.3, ENST00000621607.4, ENST00000621345.4, ENST00000369331.8, ENST00000369318.8, ENST00000672138.1, ENST00000369321.6, ENST00000345633.8, ENST00000614447.4, ENST00000369315.5 )
CASP7 p.Asp340Glu (p.D340E) ( ENST00000345633.8, ENST00000369315.5, ENST00000369318.8, ENST00000369321.6, ENST00000369331.8, ENST00000452490.3, ENST00000614447.4, ENST00000621345.4, ENST00000621607.4, ENST00000672138.1 ) - Associated Disease
- Carcinoma of lung
- Source Database
- DisGeNET
- Description
- However, we found that homozygote (G/G) of rs2227310 in the CASP-7 gene, del allele, heterozygote (ins/del), and del carrier (ins/del + del/del) of rs3834129 in CASP-8 could be protective factors for lung cancer (OR = 0.17, 95%CI = 0.14-0.21, P = 0.0003; OR = 0.83, 95%CI = 0.72-0.97, P = 0.02; OR = 0.74, 95%CI = 0.64-0.85, P < 0.0001; OR = 0.81, 95%CI = 0.71-0.93, P = 0.002; respectively).
- Pubmed
- 23315881
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00217153497664243
- Year of publication
- 2014
Drugs