Annotation Detail
Information
- Associated Genes
- CPB2
- Associated Variants
-
CPB2 p.Ala169Thr (p.A169T)
(
ENST00000674625.1,
ENST00000181383.10,
ENST00000439329.5 )
ARHGAP30 p.Arg1085= (p.R1085=) ( ENST00000368015.1, ENST00000368013.8, ENST00000368016.7 )
IL6 c.324+147C>G ( ENST00000485300.1, ENST00000407492.5, ENST00000401630.7, ENST00000401651.5, ENST00000406575.1, ENST00000258743.10, ENST00000404625.5 )
CPB2 p.Ala169Thr (p.A169T) ( ENST00000181383.10, ENST00000439329.5, ENST00000674625.1 )
ARHGAP30 p.Arg1085= (p.R1085=) ( ENST00000368013.8, ENST00000368015.1, ENST00000368016.7 )
IL6 c.324+147C>G ( ENST00000258743.10, ENST00000401630.7, ENST00000401651.5, ENST00000404625.5, ENST00000406575.1, ENST00000407492.5, ENST00000485300.1 ) - Associated Disease
- Coronary heart disease
- Source Database
- DisGeNET
- Description
- In interaction analysis we found statistical evidence of variant-gender interaction conferring risk of CHD and CVD: rs3742264 in the carboxypeptidase B2 gene, p(interaction) = 0.009 for CHD, and rs2774279 in the upstream stimulatory factor 1 gene, p(interaction) = 0.007 for CHD and CVD, showed strong association in women but not in men, while rs2069840 in interleukin 6 gene, p(interaction) = 0.004 for CVD, showed strong association in men but not in women (uncorrected p-values).
- Pubmed
- 18974842
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00345279946692324
- Year of publication
- 2008
Drugs