Annotation Detail
Information
- Associated Genes
- LTC4S
- Associated Variants
-
ALOX5 c.431+100A>G
(
ENST00000374391.7,
ENST00000542434.5 )
LTA4H c.1380-684A>G ( ENST00000552789.5, ENST00000228740.7, ENST00000413268.6 )
rs730012
ALOX5 c.431+100A>G ( ENST00000374391.7, ENST00000542434.5 )
LTA4H c.1380-684A>G ( ENST00000228740.7, ENST00000413268.6, ENST00000552789.5 )
rs730012 - Associated Disease
- Ischemic Cerebrovascular Accident
- Source Database
- DisGeNET
- Description
- Under the recessive genetic model, ALOX5 rs2029253 variant reduced IS risk (adjusted OR, 0.78; 95% CI, 0.60-1.00; P=0.048) while LTA4H rs6538697 and LTC4S rs730012 variants increased (adjusted OR, 1.66; 95% CI, 1.04-2.64; P=0.032 and adjusted OR, 3.63; 95% CI, 1.01-13.05; P=0.048, respectively).
- Pubmed
- 23079278
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00081432561624091
- Year of publication
- 2012
Drugs