Annotation Detail
Information
- Associated Genes
- SHMT1
- Associated Variants
-
SHMT1 MUTATION
SHMT1 MUTATION - Associated Disease
- severe combined immunodeficiency
- Source Database
- DisGeNET
- Description
- The expression of the PRSS3, ABCC4, TXN, SHMT1 and CMPK genes was significantly promoted in the orthotopically implanted SCID mouse model of the 4 lung cancer cell lines by the administration of S-1, while the expression of the LMO7 and FOLH1 genes was significantly suppressed.
- Pubmed
- 25405593
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 4
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs