Annotation Detail

Information
Associated Genes
SCN5A
Associated Variants
SCN5A p.Arg367Leu (p.R367L) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.Arg367His (p.R367H) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.Arg121Gln (p.R121Q) ( ENST00000449557.6, ENST00000423572.7, ENST00000450102.6, ENST00000455624.6, ENST00000333535.9, ENST00000413689.6, ENST00000414099.6 )
SCN5A p.Val95Leu (p.V95L) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.Val95Ile (p.V95I) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.Arg367Leu (p.R367L) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.Arg367His (p.R367H) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000450102.6, ENST00000455624.6, ENST00000449557.6 )
SCN5A p.Arg121Gln (p.R121Q) ( ENST00000449557.6, ENST00000450102.6, ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000455624.6 )
SCN5A p.Val95Leu (p.V95L) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.Val95Ile (p.V95I) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
Associated Disease
Brugada Syndrome (disorder)
Source Database
DisGeNET
Description
Three SCN5A mutations (V95I, R121Q, and R367H) have been previously implicated in BrS.
Pubmed
24529773
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.837036083888799
Year of publication
2013
Drugs