Annotation Detail
Information
- Associated Genes
- TLR4
- Associated Variants
-
IL13 p.Gln144Arg (p.Q144R)
(
ENST00000304506.7 )
ENSG00000285082 c.-147-423A>G, TLR4 c.94-787A>G ( ENST00000355622.8, ENST00000394487.5, ENST00000472304.2 )
IL13 p.Gln144Arg (p.Q144R) ( ENST00000304506.7 )
ENSG00000285082 c.-147-423A>G, TLR4 c.94-787A>G ( ENST00000355622.8, ENST00000394487.5, ENST00000472304.2 ) - Associated Disease
- Allergic rhinitis (disorder)
- Source Database
- DisGeNET
- Description
- Antibiotic and mold exposure in infancy, GA or AA genotypes of IL-13 (rs20541) (aOR 4.53; 95% CI, 1.66-12.38; P for interaction = .05), and CT+TT genotype of Toll-like receptor 4 (rs1927911) (aOR, 3.20; 95% CI, 1.24-8.26; P for interaction = .18) increased the risk of current AR.
- Pubmed
- 24973272
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00636271518968588
- Year of publication
- 2014
Drugs