Annotation Detail
Information
- Associated Genes
- NKX2-1
- Associated Variants
-
FOXE1 p.Ala178_Ala179del (p.A178_A179del)
(
ENST00000375123.5 )
FOXE1 p.Ala178_Ala179del (p.A178_A179del) ( ENST00000375123.5 )
rs944289
rs965513
FOXE1 c.-283A>G ( ENST00000375123.5 )
rs944289
rs965513
FOXE1 c.-283A>G ( ENST00000375123.5 ) - Associated Disease
- differentiated thyroid gland carcinoma
- Source Database
- DisGeNET
- Description
- Significant association with DTC risk was found for rs944289 near NKX2-1 (OR per A allele = 1.6, 95% CI: 1.2-2.1), and three polymorphisms near or within FOXE1, namely rs965513 (OR per A allele = 1.7, 95% CI: 1.2-2.3), rs1867277 in the promoter region of the gene (OR per A allele = 1.5, 95% CI: 1.1-1.9) and the poly-alanine tract expansion polymorphism rs71369530 (OR per Long Allele = 1.8, 95% CI: 1.3-2.5), only the 2 latter remaining significant when correcting for multiple tests.
- Pubmed
- 25879635
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00108576748832121
- Year of publication
- 2015
Drugs