Annotation Detail
Information
- Associated Genes
- MTR
- Associated Variants
-
MTRR p.Ile22Met (p.I22M)
(
ENST00000264668.6,
ENST00000440940.7 )
MTRR p.Ile22Met (p.I22M) ( ENST00000264668.6, ENST00000440940.7 ) - Associated Disease
- Malignant neoplasm of lung
- Source Database
- DisGeNET
- Description
- Functional polymorphisms in genes encoding one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T and A1,298C), methionine synthase (MTR A2,756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase, influence folate metabolism and thus might be suspected of impacting on lung cancer risk.
- Pubmed
- 17468511
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0105538954027293
- Year of publication
- 2007
Drugs