Annotation Detail
Information
- Associated Genes
- IRS1
- Associated Variants
-
TRIB3 p.Gln111Arg (p.Q111R)
(
ENST00000217233.9,
ENST00000422053.3,
ENST00000449710.6,
ENST00000615226.5,
ENST00000714424.1,
ENST00000714425.1,
ENST00000714426.1,
ENST00000714427.1,
ENST00000714428.1 )
IRS1 p.Gly971Trp (p.G971W) ( ENST00000305123.6 )
IRS1 p.Gly971Arg (p.G971R) ( ENST00000305123.6 )
IRS1 p.Gly971Arg (p.G971R) ( ENST00000305123.6 )
TRIB3 p.Gln111Arg (p.Q111R) ( ENST00000217233.9, ENST00000422053.3, ENST00000449710.6, ENST00000615226.5, ENST00000714424.1, ENST00000714425.1, ENST00000714426.1, ENST00000714427.1, ENST00000714428.1 )
IRS1 p.Gly971Trp (p.G971W) ( ENST00000305123.6 )
IRS1 p.Gly971Arg (p.G971R) ( ENST00000305123.6 )
IRS1 p.Gly971Arg (p.G971R) ( ENST00000305123.6 ) - Associated Disease
- Diabetes Mellitus, Non-Insulin-Dependent
- Source Database
- DisGeNET
- Description
- In this Review, we discuss the role of relatively infrequent polymorphisms of genes that regulate insulin signaling (including the K121Q polymorphism of ENPP1, the G972R polymorphism of IRS1 and the Q84R polymorphism of TRIB3) in T2DM and other conditions related to insulin resistance.
- Pubmed
- 19924153
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.62714418720803
- Year of publication
- 2009
Drugs