Annotation Detail
Information
- Associated Genes
- IL4
- Associated Variants
-
IL4R p.Gln576Arg (p.Q576R)
(
ENST00000543915.6,
ENST00000170630.6,
ENST00000395762.7 )
rs2243248
IL4R p.Gln576Arg (p.Q576R) ( ENST00000170630.6, ENST00000395762.7, ENST00000543915.6 )
rs2243248 - Associated Disease
- glioblastoma
- Source Database
- DisGeNET
- Description
- The genotype AG of rs1801275 in the IL-4R gene showed an increase risk in over-dominant model (OR = 2.29; 95% CI, 1.20 - 4.35; p = 0.0081) We further analyzed whether the six cytokine genes have a different effect on the disease in gender specific population, and found that the allele G of rs2243248 in the IL-4 gene showed a decrease risk of GBM in female (OR = 0.35, 95% CI, 0.13 - 0.94, p = 0.0032), but the allele T showed a decrease risk in male (OR = 0.30, 95% CI, 0.17 - 0.53, p = 0.0032).
- Pubmed
- 23663500
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00481000882732476
- Year of publication
- 2013
Drugs