Annotation Detail
Information
- Associated Genes
- ADRB1
- Associated Variants
-
ADRB1 p.Gly389Arg (p.G389R)
(
ENST00000369295.4 )
ADRB1 p.Gly389Arg (p.G389R) ( ENST00000369295.4 ) - Associated Disease
- Hypertensive disease
- Source Database
- DisGeNET
- Description
- We attempted replication of the top meta-analysis single nucleotide polymorphisms for these genes in the Global BPgen Consortium (n=34,433) and the Women's Genome Health Study (n=23,019) and found significant results for rs1801253 in ADRB1 (Arg389Gly), with the Gly allele associated with a lower mean systolic blood pressure (β: 0.57 mm Hg; SE: 0.09 mm Hg; meta-analysis: P=4.7×10(-10)), diastolic blood pressure (β: 0.36 mm Hg; SE: 0.06 mm Hg; meta-analysis: P=9.5×10(-10)), and prevalence of hypertension (β: 0.06 mm Hg; SE: 0.02 mm Hg; meta-analysis: P=3.3×10(-4)).
- Pubmed
- 21444836
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.270162958001766
- Year of publication
- 2011
Drugs