Annotation Detail
Information
- Associated Genes
- IL6
- Associated Variants
-
NFKB1 c.2592+58T>A
(
ENST00000226574.9,
ENST00000394820.8,
ENST00000505458.5,
ENST00000507079.6,
ENST00000509165.2 )
IL6 c.-85+344A>G ( ENST00000404625.5 )
IKBKB c.106-5603G>T ( ENST00000520810.6, ENST00000520835.7, ENST00000522147.4 )
NFKB1 c.2592+58T>A ( ENST00000226574.9, ENST00000394820.8, ENST00000505458.5, ENST00000507079.6, ENST00000509165.2 )
IL6 c.-85+344A>G ( ENST00000404625.5 )
IKBKB c.106-5603G>T ( ENST00000520810.6, ENST00000520835.7, ENST00000522147.4 ) - Associated Disease
- colon carcinoma
- Source Database
- DisGeNET
- Description
- The most significant finding (nominal P = 0.0004; false discovery rate q = 0.037) was a combined genotype association across IKBKB SNP rs5029748 (1 or 2 variant alleles), IL6 rs1800797 (1 or 2 variant alleles), and NFKB1 rs4648110 (2 variant alleles) which conferred an ~80% decreased risk of colon cancer.
- Pubmed
- 21129206
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00732893054616819
- Year of publication
- 2010
Drugs