Annotation Detail
Information
- Associated Genes
- IL6
- Associated Variants
-
IL6 c.-84-153C>G
(
ENST00000404625.5 )
IL6 c.-84-153C>G ( ENST00000404625.5 ) - Associated Disease
- Diabetes Mellitus, Non-Insulin-Dependent
- Source Database
- DisGeNET
- Description
- Recent studies identified a significant interaction between body mass index (BMI) and the rs1800795 polymorphism of the interleukin-6 gene that influences both IR and onset of type 2 diabetes mellitus, with obese individuals homozygous for the C allele demonstrating the highest level of IR and greatest risk for type 2 diabetes mellitus.
- Pubmed
- 22075267
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.42066159371986
- Year of publication
- 2012
Drugs