Annotation Detail
Information
- Associated Genes
- MEN1
- Associated Variants
-
MEN1 MUTATION
MEN1 MUTATION - Associated Disease
- Pituitary Diseases
- Source Database
- DisGeNET
- Description
- These data suggest that CDK4 is a critical downstream target of MEN1-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 is dispensable for tumorigenesis in these neuroendocrine cell types.
- Pubmed
- 24531709
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 12
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0130292098598546
Drugs