Annotation Detail
Information
- Associated Genes
- HTR1A
- Associated Variants
-
SLC6A2 p.Phe528Cys (p.F528C)
(
ENST00000567238.1,
ENST00000568943.6,
ENST00000561820.5,
ENST00000219833.13,
ENST00000566163.5,
ENST00000414754.7,
ENST00000379906.6 )
HTR1A p.Arg220Leu (p.R220L) ( ENST00000323865.5 )
SLC6A2 p.Phe528Cys (p.F528C) ( ENST00000219833.13, ENST00000379906.6, ENST00000414754.7, ENST00000561820.5, ENST00000566163.5, ENST00000567238.1, ENST00000568943.6 )
HTR1A p.Arg220Leu (p.R220L) ( ENST00000323865.5 ) - Associated Disease
- Mental Depression
- Source Database
- DisGeNET
- Description
- In conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the F528C NET and R219L 5-HT(1A) receptor variants in particular are involved in the pathogenesis of depression.
- Pubmed
- 19105200
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0516401022636073
- Year of publication
- 2009
Drugs