Annotation Detail
Information
- Associated Genes
- EPHB2
- Associated Variants
-
EPHB2 MUTATION
EPHB2 MUTATION - Associated Disease
- osteosarcoma
- Source Database
- DisGeNET
- Description
- Taken together, data show CTGF elevating MMPs expression and subsequently promoting tumor metastasis in human osteosarcoma, down-regulating miR-519d via MEK and ERK pathways, making CTGF a new molecular therapeutic target in osteosarcoma metastasis.
- Pubmed
- 25003330
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 11
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00162865123248182
Drugs