Annotation Detail
Information
- Associated Genes
- CTLA4
- Associated Variants
-
CTLA4 MUTATION
CTLA4 MUTATION - Associated Disease
- osteosarcoma
- Source Database
- DisGeNET
- Description
- We demonstrate that canine OS is positive for HER2, and that canine T cells expressing a HER2-specific CAR with human-derived transmembrane and CD28.ζ signaling domains recognize and kill HER2(+) canine OS cell lines in an antigen-dependent manner.
- Pubmed
- 25198528
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00162865123248182
Drugs