Annotation Detail
Information
- Associated Genes
- MMP1
- Associated Variants
-
MMP1 MUTATION
MMP1 MUTATION - Associated Disease
- Degenerative polyarthritis
- Source Database
- DisGeNET
- Description
- Using rabbit and human synovial fibroblast cell lines, we examined the effects of Cx43 overexpression and Cx43 siRNA-mediated knockdown on the gene expression of OA-associated matrix metalloproteinases (MMP1 and MMP13), aggrecanases (ADAMTS4 and ADAMTS5), and inflammatory factors (IL1, IL6 and PTGS2) by quantitative real time RT-PCR.
- Pubmed
- 25496568
- Section of the abstract supporting the evidence
- METHODS
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 3
- Original source reporting the Gene Disease association
- BeFree,LHGDN
- DisGENET score for the Gene Disease association
- 0.0138733300410879
Drugs