Annotation Detail

Information
Associated Genes
SERPINE1
Associated Variants
MMP3 SNV
MMP3 SNV
Associated Disease
cerebral infarction
Source Database
DisGeNET
Description
rs1799889 was associated with CSF PAI-1 concentrations (P = 0.048), and white patients homozygous for the low PAI-1 producing genotype (5G/5G) had a significantly higher risk for cerebral infarctions (P = 0.015) and haemorrhages (P = 0.005).
Pubmed
24248324
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.00609127331760558
Year of publication
2013
Drugs