Annotation Detail
Information
- Associated Genes
- IRS1
- Associated Variants
-
IRS1 MUTATION
IRS1 MUTATION - Associated Disease
- obesity
- Source Database
- DisGeNET
- Description
- The interaction between APPL1 and IR depends on insulin- or adiponectin-stimulated APPL1 phosphorylation, which is greatly reduced in insulin target tissues in obese mice. appl1 deletion in mice consistently leads to systemic insulin resistance and a significant reduction in insulin-stimulated IRS1/2, but not IR, tyrosine phosphorylation, indicating that APPL1 sensitizes insulin signaling by acting at a site downstream of the IR.
- Pubmed
- 24813896
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 5
- Original source reporting the Gene Disease association
- BeFree,CTD_human,GAD,RGD
- DisGENET score for the Gene Disease association
- 0.218425709693058
Drugs