Annotation Detail
Information
- Associated Genes
- ERCC4
- Associated Variants
-
ERCC4 MUTATION
ERCC4 MUTATION - Associated Disease
- neutropenia
- Source Database
- DisGeNET
- Description
- With respect to hematological and nonhematological toxicities, SNPs in drug transporters (ABCB1 and ABCG2) were associated with thrombocytopenia, nausea and neutropenia, whereas SNPs in the DNA repair pathway genes ERCC4 and XPC were significantly associated with neutropenia and sensory neuropathy, respectively.
- Pubmed
- 25340731
- Section of the abstract supporting the evidence
- RESULTS
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs