Annotation Detail

Information
Associated Genes
MSH2
Associated Variants
MSH2 p.Asn127Ser (p.N127S) ( ENST00000406134.5, ENST00000233146.7, ENST00000543555.6, ENST00000645506.1, ENST00000713854.1, ENST00000713860.1, ENST00000713861.1, ENST00000713919.1 )
MSH2 p.Asn127Ile (p.N127I) ( ENST00000233146.7, ENST00000406134.5, ENST00000543555.6, ENST00000645506.1, ENST00000713854.1, ENST00000713860.1, ENST00000713861.1, ENST00000713919.1 )
MSH2 p.Ile145Met (p.I145M) ( ENST00000233146.7, ENST00000406134.5, ENST00000543555.6, ENST00000645506.1, ENST00000713854.1, ENST00000713860.1, ENST00000713861.1, ENST00000713919.1 )
MSH2 p.Asn127Ser (p.N127S) ( ENST00000233146.7, ENST00000406134.5, ENST00000543555.6, ENST00000645506.1, ENST00000713854.1, ENST00000713860.1, ENST00000713861.1, ENST00000713919.1 )
MSH2 p.Asn127Ile (p.N127I) ( ENST00000233146.7, ENST00000406134.5, ENST00000543555.6, ENST00000645506.1, ENST00000713854.1, ENST00000713860.1, ENST00000713861.1, ENST00000713919.1 )
MSH2 p.Ile145Met (p.I145M) ( ENST00000233146.7, ENST00000406134.5, ENST00000543555.6, ENST00000645506.1, ENST00000713854.1, ENST00000713860.1, ENST00000713861.1, ENST00000713919.1 )
Associated Disease
Colorectal cancer, hereditary nonpolyposis, type 1
Source Database
DisGeNET
Description
Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients.
Pubmed
22581703
Original source reporting the Gene Disease association
UNIPROT
DisGENET score for the Gene Disease association
0.32
Year of publication
2012
Drugs