Annotation Detail
Information
- Associated Genes
- REST
- Associated Variants
-
REST c.982+414G>T
(
ENST00000309042.12,
ENST00000622863.4,
ENST00000640168.2,
ENST00000640343.2,
ENST00000675105.1,
ENST00000675341.1 )
REST c.982+414G>T ( ENST00000309042.12, ENST00000622863.4, ENST00000640168.2, ENST00000640343.2, ENST00000675105.1, ENST00000675341.1 ) - Associated Disease
- age related macular degeneration
- Source Database
- DisGeNET
- Description
- In addition to CFH (rs800292, P = 4.23 × 10(-15)) and ARMS2 (rs3750847, P = 8.67 × 10(-29)) loci, we identified two new susceptibility loci for exudative AMD: TNFRSF10A-LOC389641 on chromosome 8p21 (rs13278062, combined P = 1.03 × 10(-12), odds ratio = 0.73) and REST-C4orf14-POLR2B-IGFBP7 on chromosome 4q12 (rs1713985, combined P = 2.34 × 10(-8), odds ratio = 1.30).
- Pubmed
- 21909106
- Original source reporting the Gene Disease association
- GWASCAT
- DisGENET score for the Gene Disease association
- 0.122638473850682
- Year of publication
- 2011
Drugs