Annotation Detail
Information
- Associated Genes
- CD40LG
- Associated Variants
-
CD40 c.51+1066C>A
(
ENST00000372276.7,
ENST00000372285.8,
ENST00000695671.1 )
CD40 c.51+1066C>T ( ENST00000372276.7, ENST00000372285.8, ENST00000695671.1 )
CD40 c.51+1066C>A ( ENST00000372276.7, ENST00000372285.8, ENST00000695671.1 )
CD40 c.51+1066C>T ( ENST00000372276.7, ENST00000372285.8, ENST00000695671.1 ) - Associated Disease
- arteriosclerosis
- Source Database
- DisGeNET
- Description
- Although we did not observe a significant association of CD40-CD154 gene variants with the development of CV events, an ANCOVA model adjusted for sex, age at the time of the ultrasonography assessment, follow-up time, traditional CV risk factors and anti-cyclic citrullinated peptide antibodies disclosed a significant association (p=0.0047) between CD40 rs1535045 polymorphism and carotid intima media thickness, a surrogate marker of atherosclerosis.
- Pubmed
- 23166616
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00597172118576667
- Year of publication
- 2012
Drugs