Annotation Detail
Information
- Associated Genes
- MTHFR
- Associated Variants
-
MTHFR MUTATION
MTHFR MUTATION
MTHFR c.359+724A>G ( ENST00000641407.1, ENST00000376592.6, ENST00000376590.9, ENST00000423400.7, ENST00000376583.7, ENST00000376585.6 )
rs13162612
rs2924471
rs10475407
MTRR SNV
rs10512948
MTHFR c.359+724A>G ( ENST00000376583.7, ENST00000376585.6, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1 )
rs13162612
rs2924471
rs10475407
MTRR SNV
rs10512948 - Associated Disease
- Malignant neoplasm of lung
- Source Database
- DisGeNET
- Description
- SNPs in MTRR (rs13162612; OR = 0.25; 95% CI: 0.11-0.58; rs10512948; OR = 0.61; 95% CI: 0.41-0.90; rs2924471; OR = 3.31; 95% CI: 1.66-6.59), and MTHFR (rs9651118; OR = 0.63; 95% CI: 0.43-0.95) and three SNP*nutrient interactions (choline*rs10475407; OR = 1.62; 95% CI: 1.11-2.42; choline*rs11134290; OR = 0.51; 95% CI: 0.27-0.92; and riboflavin*rs8767412; OR = 0.40; 95% CI: 0.15-0.95) were associated with lung cancer risk in never smokers.
- Pubmed
- 23372658
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0567651602247305
- Year of publication
- 2013
Drugs