Annotation Detail
Information
- Associated Genes
- PDGFRA
- Associated Variants
-
PDGFRA MUTATION
PDGFRA MUTATION - Associated Disease
- medulloblastoma
- Source Database
- DisGeNET
- Description
- Here, we report the subgroup specific expression of PDGFRα and PDGFRβ and their associated biological pathways in MB tumors. c-MYC, a downstream target of PDGFRβ but not PDGFRα, is involved in PDGFRβ signaling associated with cell proliferation, cell death, and invasion.
- Pubmed
- 25576913
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 3
- Original source reporting the Gene Disease association
- BeFree,CTD_human,LHGDN
- DisGENET score for the Gene Disease association
- 0.123538675858708
Drugs