Annotation Detail
Information
- Associated Genes
- TNF
- Associated Variants
-
IFNGR2 p.Gln83Arg (p.Q83R)
(
ENST00000290219.11,
ENST00000381995.5,
ENST00000405436.5 )
IL12A c.*121G>A ( ENST00000305579.7, ENST00000466512.1, ENST00000699704.1 )
IL13 p.Gln144Arg (p.Q144R) ( ENST00000304506.7 )
IL7R p.Val138Ile (p.V138I) ( ENST00000303115.8, ENST00000506850.5 )
IFNGR2 p.Gln83Arg (p.Q83R) ( ENST00000290219.11, ENST00000381995.5, ENST00000405436.5 )
IL12A c.*121G>A ( ENST00000305579.7, ENST00000466512.1, ENST00000699704.1 )
IL13 p.Gln144Arg (p.Q144R) ( ENST00000304506.7 )
IL7R p.Val138Ile (p.V138I) ( ENST00000303115.8, ENST00000506850.5 ) - Associated Disease
- chronic lymphocytic leukemia
- Source Database
- DisGeNET
- Description
- After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
- Pubmed
- 20952689
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0212359363273101
- Year of publication
- 2011
Drugs